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Although the men on testosterone did eventually have more lean body mass and less fat mass compared to those on the placebo, they did not have improved functional mobility, muscle strength, cognition function or bone mineral density, the researchers...

Although the men on testosterone did eventually have more lean body mass and less fat mass compared to those on the placebo, they did not have improved functional mobility, muscle strength, cognition function or bone mineral density, the researchers found. Those on testosterone did have improved insulin sensitivity, but HDL (high-density lipoprotein) cholesterol went down - HDL is the good cholesterol.
By the end of the six month period 47.8% of those on health
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health testosterone versus 35.5% of those on the placebo had metabolic syndrome - not considered a statistically significant difference.
The researchers report that quality-of-life measures were not different among the two groups, except for hormone-related quality of life. Adverse events between the two groups were not statistically different.
Testosterone supplementation was linked to an increase in blood creatinine concentrations, a measure of kidney function, and hemoglobin and hematocrit, two red blood cell measures. They also detected no negative effects on prostate safety from testosterone supplementation.
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The researchers wrote "This study is, as far as we know, the largest study of testosterone supplementation with the most end points and a randomized, double-blind design. Adherence was high and the dropout rate was low. The findings in this study do not support a net benefit on several indicators of health and functional and cognitive performance with 6 months of modest testosterone supplementation in healthy men with circulating testosterone levels in the lower range."
"Effect of Testosterone Supplementation on Functional Mobility, Cognition, and Other Parameters in Older Men - A Randomized Controlled Trial"
Marielle H. Emmelot-Vonk, MD; Harald J. J. Verhaar, MD, PhD; Hamid R. Nakhai Pour, MD, PhD; Andre Aleman, PhD; Tycho M. T. W. Lock, MD; J. L. H. Ruud Bosch, MD, PhD; Diederick E. Grobbee, MD, PhD; Yvonne T. van der Schouw, PhD
Approximately one in every 500 to 650 baby boys is born with an extra X chromosome, a variation in their genetic code that until a few years ago was thought to result in infertility in all cases. However, this is no longer the case. A recent conference hosted by NewYork-Presbyterian Hospital/Weill Cornell Medical Center and advocacy organization KS&A focused on raising awareness of the condition and the recent availability of treatments for both children and adults.
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As recently as 10 years ago, all men born with an extra X chromosome -- a condition whose classic symptoms are known as Klinefelter syndrome -- were thought to be infertile. Now, new research at NewYork-Presbyterian/Weill Cornell, led by Dr. Peter Schlegel, has pioneered a surgical approach -- a combination of TESE (testicular sperm extraction) and IVF (in vitro fertilization) -- that enables these men to father healthy children approximately 40 percent of the time it is employed.
But this is just the beginning. "Our Department has five scientists who are leading research into Klinefelter's and other chromosomal variations. We are very pleased to join forces with KS&A to raise awareness for these conditions," says Dr. Schlegel, chairman of the Department of Urology and professor of urology and reproductive medicine at Weill Cornell Medical College, and urologist-in-chief at NewYork-Presbyterian/Weill Cornell.
KS&A presented Dr. Schlegel with a "Lifetime Achievement Award" at its recent meeting to honor his infertility treatment advances -- which are rewriting the textbook on Klinefelter syndrome.
"Our current research in the laboratory focuses on understanding the mechanism by which the presence of an additional X chromosome affects sperm production andgreatstress
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health with Klinefelter syndrome. These critical and unique studies will allow us to provide improved treatment and management recommendations based on solid understanding of underlying pathophysiology," says Dr. Darius A. Paduch, assistant professor of urology and reproductive medicine at Weill Cornell Medical College and assistant attending urologist at NewYork-Presbyterian/Weill Cornell.
Dr. Paduch, who leads NewYork-Presbyterian/Weill Cornell's translational research into the molecular biology and genetics of 47XXY and Klinefelter syndrome, has assembled a diverse group of scientists from Cornell-Ithaca and Rockefeller University to create a center of excellence in research on Klinefelter syndrome. The Center will be one of the first nationally comprehensive resources for patients of all ages dedicated to variations in the X and Y chromosomes.
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The unique meeting brought together national expertise in molecular biology and genetics of reproduction and molecular endocrinology. Each of the scientists who participated in the conference -- Weill Cornell's Dr. Matthew Hardy, an adjunct professor of urology, and Cornell-Ithaca's Dr. Paula Cohen, associate professor of genetics, as well as Dr. Alex Travis, assistant professor of reproductive biology -- offer unique expertise in basic science, which, combined with access to patients seen in the Department of Urology, will allow for multidisciplinary collaborations focused on basic scientific research to improve patient care.
"We are very pleased to join with NewYork-Presbyterian/Weill Cornell, whose important research is a cornerstone for a growing body of knowledge that will help transform the lives of individuals who have X and Y chromosome variations," says Robert Shelton, chairman of the Board of Directors of KS&A. "There is a high likelihood that research into these chromosomal variations will make substantial contributions to knowledge about breast cancer, learning disabilities and other seemingly unrelated phenomena as more is discovered concerning the relevance of genes located on the X and Y chromosomes."
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Most individuals have a total of 46 chromosomes. Commonly, men have one X and one Y chromosome; and women have two X chromosomes. But this is not true for everyone. The most common variation is 47XXY in boys and Trisomy X in girls. Without proper interventions, boys born with an extra X chromosome are at a significantly heightened risk of developing the signs and symptoms of Klinefelter syndrome as adults. Unlike other genetic syndromes such as Down's or Fragile X, comparatively little is known about X and Y chromosome variations. NewYork-Presbyterian/Weill Cornell and KS&A are working diligently to change that.
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Isolagen initiates a Phase III clinical program to investigate Isolagen Therapy for the treatment of moderate to severe acne scars. Isolagen also has a pivotal Phase III clinical program underway to evaluate the Isolagen Therapy in treating nasolabial folds, or wrinkles.

"Millions of people in the U.S. suffer from acne which often scars, a condition that can be very distressing and difficult to treat as there are few options currently available," said Nicholas L. Teti, Jr., Chairman and Chief Executive Officer of Isolagen. "We are pleased to be initiating this important clinical development program which we believe will address this largely unmet medical need."
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Posted by WORLDINSOFT on Mon 14 Apr 2008 09:09:32 AM PDT