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Investigating Isolagen Therapy For Treatment Of Acne Scars

Isolagen initiates a Phase III clinical program to investigate Isolagen Therapy for the treatment of moderate to severe acne scars. Isolagen also has a pivotal Phase III clinical...

Investigating Isolagen Therapy For Treatment Of Acne Scars

Isolagen initiates a Phase III clinical program to investigate Isolagen Therapy for the treatment of moderate to severe acne scars. Isolagen also has a pivotal Phase III clinical program underway to evaluate the Isolagen Therapy in treating nasolabial folds, or wrinkles.
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"Millions of people in the U.S. suffer from acne which often scars, a condition that can be very distressing and difficult to treat as there are few options currently available," said Nicholas L. Teti, Jr., Chairman and Chief Executive Officer of Isolagen. "We are pleased to be initiating this important clinical development program which we believe will address this largely unmet medical need."
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Two randomized, double-blind, placebo-controlled trials will evaluate the safety and efficacy of Isolagen Therapy in patients with moderate to severe acne scarring on both sides of the face. All patients in the study will receive active treatment on one side of the face and placebo on the other, serving as their own control subjects. The patients will receive three injections, two weeks apart, and be followed for a four month period after final injection.
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Acne is one of the most common skin disorders in the United States. viagra online Buy Viagra order viagra Over time, as facial tone declines and facial fat stores are depleted, acne scars typically become more noticeable. Current treatments for acne scarring include dermabrasion, laser resurfacing, surgical excision, and certain.
Aesthera's Breakthrough Painless Isolaz Therapy For Acne

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Aesthera Corporation's Isolaz painless acne therapy has been featured in the September issue of Vogue, the most widely read issue of the year. Featured as a unique treatment that gets rid of acne fast, the Isolaz therapy is mentioned as the first laser approved by the FDA to treat severe acne.

"I haven't been this excited by a treatment in years," stated Jancee Dunn, Contributing Beauty Writer for Vogue and author of the piece. "The Isolaz completely cleared up the acne that had plagued me for ten years and vanquished all of my fine lines and sun damage. After the treatments, I could not stop touching my velvety skin. I am making standing appointments every month."
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Ms. Dunn's dermatologist, the renowned Dr. Frederic Brandt is also a fan of the treatment, "The Isolaz painless laser facial is one of the most innovative and effective in-office treatments for acne and skin rejuvenation that I have seen in years."

Aesthera's Isolaz is the only system FDA cleared to treat comedonal and pustular acne. The Isolaz therapy is also cleared to treat mild to moderate, inflammatory acne and acne vulgaris

In addition to Vogue, the Isolaz therapy has also been featured in the August issue of Harper's Bazaar and the September issue of Elle magazine as a new breakthrough treatment to effectively minimize and clear pores on a long- term basis.
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A recent clinical study also showed that, in addition to acne reduction, 64 percent of acne patients who had not responded to oral medications, topicals and traditional lasers in the past had shown greater than a 75 percent clearance of acne lesions after treatment with the Isolaz system. After four treatments, an 88 percent reduction in papular, pustular, comedonal and nodular acne was observed.

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A previously unknown side effect of an unnamed drug currently on the marketplace could be useful for treating acne, reports Chemistry & Industry, the magazine of the SCI. A UK company is about to start a Phase 1 trial with the drug involving 18 healthy human volunteers and the results are expected to be announced later this year. In an earlier Phase 1 study in nine healthy human volunteers, the treatment was seen to reduce the excretion of sebum by the skin, which is associated with acne development, by up to 70%.
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'The Phase I results are startlingly good,' said Nigel Blackburn, director of clinical development at the company, Summit, which is organising the trial. 'Reducing sebum production has been the "holy grail" of acne treatment for 30 years, and there has been little success aside from Roaccutane which has significant side effects.'
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The current 'gold standard' for acne treatment, Roaccutane can cause a wide range of side effects, including teratogenicity a€“ which leads to abonormalities in the unborn foetus of pregnant women, and has also recently been linked to depression and (inconclusively) to teenage suicides. The market for acne treatments is worth several billion dollars, and any new treatment developed without side effects could potentially reap blockbuster sales.

Although Summit has not disclosed the name of the drug now under evaluation, the company says it represents an entirely new class of compounds for treating acne. 'At the doses we are looking at any side effects should be mild compared with those resulting from Roaccutane treatment,' Blackburn commented.
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The company hopes to begin critical Phase 2 trials to assess the efficacy of the drug in acne sufferers next year. Depending on the results, the drug could either be formulated as a stand-alone topical treatment or more likely in combination with other existing treatments. The company has already been in talks with several interested companies, who are waiting to see whether the initial results can be repeated in a larger study group.

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