How would i make gallery look like an art site example...

I'm trying to build an art site. I want the main page to look as the gallery does. With obviously more options, such as news link, and others.
I want to make it look like an art site, have users signing up, them uploading there own work, have it commented on etc. Also contains a forum integration. But its not embedded in to the design, as i dont like that.

Trying to make a site that has a great script like deviantart.com has. Can anyone tell me if this is possible? if so how would i enter more links, make a completely unique design (or find good designs) etc.